Tal Medical is developing a novel, non-invasive, sub-threshold neurostimulation platform to target brain disorders.

Low Field Magnetic Stimulation (LFMS) produces a sub-threshold electric field that can modulate brain circuitry involved in unipolar and bipolar depression. The technology was serendipitously discovered at McLean Hospital when bipolar patients unexpectedly reported an immediate mood elevating effect following a custom MRI protocol in a research study.

LFMS utilizes a unique magnetic field waveform, with a mechanism of action different than those of existing neurostimulation treatments, including electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS). The key differences between LFMS and other neurostimulation platforms are as follows:

Technique

Type

Field

Intensity*

Low Field Magnetic Stimulation
(LFMS)

External

Magnetic

Sub-threshold

Transcranial magnetic stimulation
(TMS)

External

Magnetic

Above threshold

Electroconvulsive therapy
(ECT)

External

Electric

Above threshold

Transcranial direct or alternating current stim.
(tDCS/tACS)

External

Electric

Sub-threshold

Deep brain stimulation
(DBS)

Implanted

Electric

Above threshold

*Relative to neuronal firing threshold

LFMS has two additional key differences compared to other neurostimulation techniques:

  • Imperceptibility. LFMS does not cause any physical sensations, induce skin irritation, or headaches. This property of LFMS also allows the ability to run robust controlled studies with a sham treatment indistinguishable from the active treatment.
  • Safety. LFMS is based on safe, widely used, FDA-approved MRI technology; some studies estimate 30 million MRIs are administered annually in the US alone. Furthermore, in LFMS studies to date, no adverse events have been associated with LFMS treatment in over 450 subjects. 

 

Currently, we are developing a rationally designed neurostimulation approach for sleep that is guided by our knowledge of sleep architecture. This approach utilizes certain components of the LFMS platform, but uses a magnetic field with different parameters, as well as a different treatment delivery device, a wearable sleepcoil. This project is in its early stages.

The Tal Medical LFMS Device is limited by US Federal Law to Investigational Use.