Tal Medical is developing a novel, non-invasive, sub-threshold neuromodulation platform to target brain disorders.

Low Field Magnetic Stimulation (LFMS) produces a sub-threshold electric field that can modulate brain circuitry involved in depression. The technology was serendipitously discovered at McLean Hospital when bipolar patients unexpectedly reported an immediate mood elevating effect following a custom magnetic resonance spectroscopy protocol in a research study.

LFMS utilizes a unique magnetic field waveform, with a mechanism of action different from those of other neurostimulation treatments, including electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS) or deep brain stimulation (DBS). The key differences between LFMS and other neurostimulation platforms are as follows:

Technique

Type

Field

Intensity*

LFMS

External

Magnetic

Sub-threshold

TMS

External

Magnetic

Above threshold

ECT

External

Electric

Above threshold

tDCS/tACS

External

Electric

Sub-threshold

DBS

Implanted

Electric

Above threshold

*Relative to neuronal firing threshold

LFMS has two additional key differences compared to other neurostimulation techniques:

  • Imperceptibility. LFMS does not cause any physical sensations, induce skin irritation, or headaches. This property of LFMS also allows for the ability to run robust controlled studies with a sham treatment indistinguishable from the active treatment.
  • Safety. LFMS utilizes magnetic waveform parameters that are within the range used by the FDA-approved MRI technology. With about 400  subjects studied to date, LFMS has shown no major side effects. Furthermore, the FDA granted a non-significant risk designation to our highest dose study – a designation that is reserved for only very safe treatments. 

Currently, we are developing a rationally designed neurostimulation approach for sleep that is guided by our knowledge of sleep architecture. This approach utilizes certain components of the LFMS platform, but uses a magnetic field with different parameters, as well as a different treatment delivery device, a wearable sleepcoil. This project is in its early stages.

The Tal Medical LFMS Device is limited by US Federal Law to Investigational Use.